In the recently completed 12 week Phase IIb clinical trial in 494 patients with type 2 diabetes mellitus (T2DM), ‘Melogliptin’, Glenmark’s investigational medicine from a new class of diabetes treatments called dipeptidyl peptidase 4 (DPP-4) inhibitors, improved glycemic control in patients with type 2 diabetes mellitus and exhibited excellent safety and tolerability profile.

Spherix Incorporated (Nasdaq CM: SPEX), an innovator in biotechnology for diabetes therapy, and a provider of technical and regulatory consulting services to food, supplement, biotechnology and pharmaceutical companies, announced positive preliminary results from a Phase 2 clinical trial of its novel compound, Naturlose(R) (D-tagatose), in the treatment and management of Type 2 diabetes.

Scientists have identified five genetic biomarkers that could help lead to improved treatments, with fewer side effects, for patients with diabetes.

Diabetes UK would like to say a huge ‘thank you’ to everyone who helped to make this year’s Diabetes Week such a great success - we could not have done it without you. Throughout the week our volunteers, supporters and staff have been busy raising funds and diabetes awareness. Of the thousands of events that went on across the country, here are just a few of the Diabetes Week highlights.

LITTLE FALLS, N.J. (MedPage Today) — Twenty-somethings who aren’t physically fit may be at an increased risk of developing diabetes in middle age, researchers said.

Obesity is probably the most important factor in the development of insulin resistance, but science’s understanding of the chain of events is still spotty. Now, researchers at the Salk Institute for Biological Studies have filled in the gap and identified the missing link between the two.

On June 12, the Heart and Diabetes Center NRW in Bad Oeynhausen, Germany, performed the 800th implant of the SynCardia temporary CardioWest™ Total Artificial Heart. The 60-year-old patient, who was suffering from biventricular failure, was listed in stable condition post-implant. “This was our 129th implant of the Total Artificial Heart,” said implanting surgeon Dr.

Obesity is probably the most important factor in the development of insulin resistance, but science’s understanding of the chain of events is still spotty. Now, researchers have filled in the gap and identified the missing link between the two.

Most healthy 25 year olds don’t stay up at night worrying whether they are going to develop diabetes in middle age. But many should be concerned. Researchers have found young adults with low aerobic fitness levels are two to three times more likely to develop diabetes in 20 years than those who are fit.

In research that could lead to new approaches for the treatment of type 2 diabetes, scientists have found that suppressing a liver enzyme that induces glucose production helped diminish the symptoms of the disease in a rat model — reducing blood glucose concentrations, decreasing rates of glucose production in the liver, and improving insulin sensitivity.  Decreasing expression of the gene, Sirtuin 1, also lowered total cholesterol levels.